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Article
January 1987

Low-Dose Autologous In Vitro Opsonized Erythrocytes: Radioimmune Method and Autologous Opsonized Erythrocytes for Refractory Autoimmune Thrombocytopenic Purpura in Adults

Arch Intern Med. 1987;147(1):105-108. doi:10.1001/archinte.1987.00370010105024
Abstract

• Adult patients with chronic autoimmune thrombocytopenic purpura (ATP), which proved refractory to various treatments, received a single dose of autologous in vitro opsonized erythrocytes with 100 μg of anti-D IgG. In 1983, 30 of these patients were treated with autologous erythrocytes that had been opsonized and labeled with 25 mCi (740 MBq) of technetium Tc 99m; this treatment was designated as the radioimmune method. Favorable responses were noted in 36% of patients so treated. In 1985, another group of 16 patients with refractory ATP received therapy with autologous opsonized erythrocytes (AOPE) and 55% of these patients showed favorable responses. Five (17%) of the patients treated using the radioimmune method attained a complete, long-term (>35 months) remission of their ATP, and five (31%) of the patients treated using AOPE remained in complete remission over 270 days after cessation of therapy. Major complications were not seen. We concluded that the interaction of macrophages with low-dose AOPE is a successful therapeutic approach in ATP refractory to standard treatment.

(Arch Intern Med 1987;147:105-108)

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