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January 1987

Low-Dose Autologous In Vitro Opsonized Erythrocytes: Radioimmune Method and Autologous Opsonized Erythrocytes for Refractory Autoimmune Thrombocytopenic Purpura in Adults

Author Affiliations

From the Departments of Hematology (Drs Ambriz, Pizzuto, Morales, and Aviles), Nuclear Medicine (Dr Muñóz), and Immunology (Ms Quintanar), General Hospital and Central Blood Bank, National Medical Center, Mexico City.

Arch Intern Med. 1987;147(1):105-108. doi:10.1001/archinte.1987.00370010105024

• Adult patients with chronic autoimmune thrombocytopenic purpura (ATP), which proved refractory to various treatments, received a single dose of autologous in vitro opsonized erythrocytes with 100 μg of anti-D IgG. In 1983, 30 of these patients were treated with autologous erythrocytes that had been opsonized and labeled with 25 mCi (740 MBq) of technetium Tc 99m; this treatment was designated as the radioimmune method. Favorable responses were noted in 36% of patients so treated. In 1985, another group of 16 patients with refractory ATP received therapy with autologous opsonized erythrocytes (AOPE) and 55% of these patients showed favorable responses. Five (17%) of the patients treated using the radioimmune method attained a complete, long-term (>35 months) remission of their ATP, and five (31%) of the patients treated using AOPE remained in complete remission over 270 days after cessation of therapy. Major complications were not seen. We concluded that the interaction of macrophages with low-dose AOPE is a successful therapeutic approach in ATP refractory to standard treatment.

(Arch Intern Med 1987;147:105-108)

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