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Drs Rosner and Zarrabi are, of course, correct that splenectomy has been cited as a risk factor for both acquiring and dying of pneumococcal infections. In our population, one patient and one control subject had undergone a splenectomy. While the rate of splenectomy in the patients with pneumococcal infections is somewhat higher than in the uninfected control subjects (1.6% vs 0.8%), this difference is too small to achieve statistical significance. Thus, we cannot comment on splenectomy as a risk factor for acquiring pneumococcal infections based on the data obtained from our study.
Lipsky BA. Risk Factors for Acquiring Pneumococcal Infections-Reply. Arch Intern Med. 1987;147(2):212. doi:10.1001/archinte.1987.00370020032026
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