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April 1987

ß-Adrenergic Blocking Agents in the Treatment of Hypertension: Choices Based on Pharmacological Properties and Patient Characteristics

Author Affiliations

From the Section of Nephrology, Department of Medicine, Tulane University School of Medicine, and the Veterans Administration Medical Center, New Orleans.

Arch Intern Med. 1987;147(4):654-659. doi:10.1001/archinte.1987.00370040036007

• Drugs that block β-adrenergic receptors have become one of the most widely used classes of drugs to treat hypertension. This review puts the use of β-blockers as monotherapy for hypertension in perspective and provides reasons for choosing among the several β-blockers available. The major reasons for discriminating within this class of drugs are related to differences in concomitant clinical conditions, differences in patient responses, and intrinsic differences among the β-blockers. These differences relate to special properties such as β-agonist activity (intrinsic sympathomimetic activity), β1-selectivity, and concomitant α-blockade, as well as differences in side effect profiles, excretion characteristics, and length of action of the various drugs.

(Arch Intern Med 1987;147:654-659)

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