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May 1987

Sicca Complex and Infection With Human Immunodeficiency Virus

Author Affiliations

From the Departments of Immunology and INSERTA 4108 (Drs Couderc, Danon, and Clauvel), Pathology (Drs D'Agay and Brocheriou), and Virology (Dr Harzic), St Louis Hospital, Paris.

Arch Intern Med. 1987;147(5):898-901. doi:10.1001/archinte.1987.00370050094016

• Five male patients with the persistent generalized lymphadenopathy syndrome also had a sicca complex. Salivary gland biopsy specimens showed diffuse lymphocytic infiltration of the glandular parenchyma. Serum autoantibodies and rheumatoid factor were not detected. All patients had IgG antibodies to human immunodeficiency virus and IgG to the viral capsid antigen of Epstein-Barr virus. These five patients had benign lymphocytic infiltrates in other organs (lung, liver, and kidneys). Sicca complex may be one of the various manifestations of the lymphoid hyperplasia noted in human immunodeficiency virus—infected patients. In these patients, the sicca complex showed specific features related to male predominance, lack of serum autoantibodies, and peripheral-blood T-lymphocyte subset distribution.

(Arch Intern Med 1987;147:898-901)