• The initial primary defect in the development of neuro-osteoarthropathy is neuropathy. Our case reports and a review of the literature strongly implicate a neurally initiated vascular reflex leading to increased blood flow. This may play a pivotal role in the development of Charcot's joint in the neuropathic limb. Mechanical trauma in an insensitive foot is contributory, but it is probably a secondary mechanism.
(Arch Intern Med 1987;147:1504-1508)
Edelman SV, Kosofsky EM, Paul RA, Kozak GP. Neuro-osteoarthropathy (Charcot's Joint) in Diabetes Mellitus Following Revascularization Surgery: Three Case Reports and a Review of the Literature. Arch Intern Med. 1987;147(8):1504–1508. doi:10.1001/archinte.1987.00370080142027
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