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December 1987

Clinical Features of 100 Human Immunodeficiency Virus Antibody—Positive Individuals From an Alternate Test Site

Author Affiliations

From the Edmund D. Edelman Health Center (Drs Howard and Sperling), and the Division of Infectious Diseases, Department of Medicine, University of Southern California School of Medicine (Drs Sattler and Leedom and Mr Mahon), Los Angeles.

Arch Intern Med. 1987;147(12):2131-2133. doi:10.1001/archinte.1987.00370120067013

• We evaluated 100 human immunodeficiency virus (HIV) antibody—positive persons from the only alternate test site in Los Angeles. Thirty-five subjects complained of systemic symptoms suggestive of HIV infection and 65 were completely asymptomatic. Irrespective of symptoms, the group as a whole demonstrated clinical and laboratory evidence of immunodeficiency. Eighty had generalized lymphadenopathy, 16 onychomycosis, six oral candidiasis, and two biopsy-proved Kaposi's sarcoma. Seventy-seven were anergic to seven intradermal antigens. Despite normal white blood cell counts in most subjects, the T-helper-cell count was less than 300/mm3 in 48% of asymptomatic and 46% of symptomatic subjects. The degree of immune depression was less severe but approximated that of patients with acquired immunodeficiency syndrome after Pneumocystis carinii pneumonia. We believe these findings justify the need for comprehensive medical evaluation and follow-up care for seropositive persons from alternate test sites.

(Arch Intern Med 1987;147:2131-2133)