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April 1988

Characterization of the Acute Clinical Illness Associated With Human Immunodeficiency Virus Infection

Author Affiliations

NHMRC Special Unit in AIDS Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia; Centre for Immunology, St Vincent's Hospital, Sydney, Australia; Albion Street Centre, Sydney Hospital; Sexually Transmissible Disease Centre, Sydney Hospital; School of Public Health and Tropical Medicine, Sydney University

From the Centre of Immunology, St Vincent's Hospital, Sydney, Australia (Mr Tindall and Drs Barker, and Penny); National Health and Medical Research Council of Australia (NHMRC) Special Unit in AIDS Epidemiology and Clinical Research, University of New South Wales, Sydney (Dr Cooper and Ms Kronenberg); the Sexually Transmissible Disease Centre (Ms Roberts), and the Albion Street Centre (Dr Gold), Sydney Hospital. Drs Donovan and Barnes are in private practice in Sydney.

Arch Intern Med. 1988;148(4):945-949. doi:10.1001/archinte.1988.00380040185026

• The clinical and serologic features and immune status of 39 homosexual men who had seroconversion to human immunodeficiency virus positivity were compared with 26 homosexual men who remained seronegative during a six-month period. An acute clinical Illness occurred in 92.3% of seroconverted subjects and 40% of controls. The duration of illness was significantly greater In the seroconverters than the controls (10 + 4.4 days). A general practitioner was consulted by 87.2% of the seroconverters because of the illness, including 12.8% who were admitted to hospital, compared with 20% of controls. The most frequently reported symptoms In the seroconversion group were fever (76.9%); lethargy and malaise (66.7%); anorexia, sore throat, and myalgias (56.4% each); headaches and arthralgias (48.7% each); weight loss (46.2%); swollen glands (43.5%); retro-orbital pain (38.5%); and dehydration and nausea (30.8% each). Lymphadenopathy developed in 75% of seroconverters compared with 4% of controls. Changes in T-cell subsets were not found in controls, but the number of T4 + cells and the T4 + /T8 + ratio decreased significantly in seroconverters.

(Arch Intern Med 1988;148:945-949)

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