• The clinical and serologic features and immune status of 39 homosexual men who had seroconversion to human immunodeficiency virus positivity were compared with 26 homosexual men who remained seronegative during a six-month period. An acute clinical Illness occurred in 92.3% of seroconverted subjects and 40% of controls. The duration of illness was significantly greater In the seroconverters than the controls (10 + 4.4 days). A general practitioner was consulted by 87.2% of the seroconverters because of the illness, including 12.8% who were admitted to hospital, compared with 20% of controls. The most frequently reported symptoms In the seroconversion group were fever (76.9%); lethargy and malaise (66.7%); anorexia, sore throat, and myalgias (56.4% each); headaches and arthralgias (48.7% each); weight loss (46.2%); swollen glands (43.5%); retro-orbital pain (38.5%); and dehydration and nausea (30.8% each). Lymphadenopathy developed in 75% of seroconverters compared with 4% of controls. Changes in T-cell subsets were not found in controls, but the number of T4 + cells and the T4 + /T8 + ratio decreased significantly in seroconverters.
(Arch Intern Med 1988;148:945-949)
Tindall B, Barker S, Donovan B, et al. Characterization of the Acute Clinical Illness Associated With Human Immunodeficiency Virus Infection. Arch Intern Med. 1988;148(4):945–949. doi:10.1001/archinte.1988.00380040185026
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