[Skip to Navigation]
May 1988

Carotid Sinus Syndrome Associated With an Occult Primary Nasopharyngeal Carcinoma

Author Affiliations

From the Medical Service, Washington Veterans Administration Medical Center (Drs Tulchinsky and Krasnow), and the Department of Medicine, George Washington University Medical Center (Dr Krasnow), Washington, DC.

Arch Intern Med. 1988;148(5):1217-1219. doi:10.1001/archinte.1988.00380050221031

• A patient presented with syncope, and a diagnosis of carotid sinus syndrome was established. Further evaluation revealed a large nasopharyngeal carcinoma invading the left petrous bone. There were no cervical metastases. The tumor partially regressed with radiation therapy, and there was complete resolution of the carotid sinus syndrome, but the patient died three months later of metastatic disease. Autopsy confirmed petrous bone involvement by the mass but no cervical metastatic disease. This Is the first reported case (to our knowledge) of malignancy-associated carotid sinus syndrome attributable to a primary nasopharyngeal carcinoma. The literature on malignancy-associated carotid sinus syndrome Is reviewed, with emphasis on pathophysiology and treatment.

(Arch Intern Med 1988;148:1217-1219)

Add or change institution