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June 1988

Renal Function in Patients With Obstructive Sleep Apnea: Effects of Nasal Continuous Positive Airway Pressure

Author Affiliations

From the EEG Department, University Hospital (Drs Krieger and Kurtz); and the Institute of Pharmacology, Faculty of Medicine (Drs Imbs and Schmidt), Strasbourg, France.

Arch Intern Med. 1988;148(6):1337-1340. doi:10.1001/archinte.1988.00380060101020

• Patients with obstructive sleep apnea (OSA) often exhibit nocturnal polyuria, which disappears with nasal continuous positive airway pressure (CPAP) treatment. We measured water and electrolyte urinary excretion, creatinine and osmolal clearances, and water transport during sleep in 13 polygraphically monitored patients with OSA during two consecutive nights, either untreated or treated with nasal CPAP, and in eight normal subjects. Untreated patients with OSA had greater urinary flows and greater urinary sodium, chloride, and potassium excretions than did controls. Nasal CPAP treatment in patients with OSA resulted in a reduction in urinary flow and in sodium and chloride excretion, with a concomitant increase in sodium resorption. None of these effects was observed in CPAP-treated normal subjects. The only effect of nasal CPAP common to normal subjects and patients was a trend toward decreased glomerular filtration rate.

(Arch Intern Med 1988;148:1337-1340)