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September 1988

Verapamil vs Quinine in Recumbent Nocturnal Leg Cramps in the Elderly

Author Affiliations

From the Division of Clinical Pharmacology, University of Miami School of Medicine.

Arch Intern Med. 1988;148(9):1969-1970. doi:10.1001/archinte.1988.00380090055015

• In an open-labeled trial with eight elderly patients (aged 62 to 87 years) suffering from nocturnal leg cramps refractory to treatment with quinine sulfate, we ruled out other active disease processes and substituted verapamil hydrochloride therapy (120 mg at bedtime). Response to treatment was assessed by biweekly observations by the primary care physician and nightly by the research registered nurse for the entire duration of the trial, lasting eight weeks. Observations made and clinical conditions reported were indicative of improvement and disappearance of cramping when therapy was changed from quinine to verapamil. This noteworthy improvement in patients with recumbent nocturnal leg cramps is an important finding and merits further investigation.

(Arch Intern Med 1988;148:1969-1970)

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