[Skip to Navigation]
September 1988

Use of Antimicrobial Agents in a University Teaching Hospital: Evolution of a Comprehensive Control Program

Author Affiliations

From the Division of Infectious Diseases (Drs Hirschman and Meyers), Department of Medicine, the Pharmacy Department (Mr Bradbury and Drs Mehl and Kimelblatt), and The Department of Neurology (Dr Gendelman), The Mount Sinai School of Medicine of the City University of New York and The Mount Sinai Hospital, New York.

Arch Intern Med. 1988;148(9):2001-2007. doi:10.1001/archinte.1988.00380090079020

• A comprehensive control program for utilization of antimicrobial agents in a large tertiary university teaching hospital regulates both dosage and duration of therapy and requires the prior approval of an infectious disease specialist for utilization of restricted antimicrobial agents. Benefits of the program include more cost-effective antimicrobial therapy and increased physician education in the use of these drugs. Gross savings in pharmacy costs for antibiotics during the first year of the program (1985) amounted to $483032 for an average monthly savings of $40252. Gross savings for 1986 were $211 786 with monthly savings of $17648. The control of the use of one agent may lead to overuse of another agent. Antimicrobial prescribing patterns of physicians are quickly influenced by changing regulations of the program. An ongoing surveillance and review program of in-hospital utilization of antimicrobial agents is necessary to maintain effective and flexible controls.

(Arch Intern Med 1988;148:2001-2007)

Add or change institution