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February 1989

Passive Smoking Affects Endothelium and Platelets

Author Affiliations

Joyce Arnold

From the Veterans Administration Medical Center, Kansas City, Mo (Drs Davis and Watanabe); and the Departments of Medicine (Dr Davis and Mss Shelton and Arnold) and Pathology (Dr Watanabe), University of Kansas School of Medicine, Kansas City.

Arch Intern Med. 1989;149(2):386-389. doi:10.1001/archinte.1989.00390020096020

• Blood was obtained before and after ten healthy male nonsmokers sat for 20 minutes in open hospital corridors beside men who were already there smoking by their own initiative. Mean values before and after passive smoking were 0.87 and 0.78 for the platelet aggregate ratio, 2.8 and 3.7 per counting chamber for the endothelial cell count, 0 and 2.8 ng/mL for the plasma nicotine concentration, and 0.9% and 1.3% for the carboxyhemoglobin level. No variable changed significantly during control periods in which the subjects sat in a room where smoking was prohibited. Passive exposure to tobacco smoke affected the endothelial cell count and platelet aggregate ratio in a manner similar to that previously observed with active smoking.

(Arch Intern Med 1989;149:386-389)

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