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February 1989

Left Atrial Myxoma Associated With Systemic AA Amyloidosis

Author Affiliations

From the Departments of Internal Medicine (Drs Wens, Kutnowski, DeCoodt, and Verbanck), Pathology (Dr Goffin), and Microbiology (Dr Van Beers), Brugmann University Hospital, Brussels, and the Department of Medicine, Royal Postgraduate Medical School, London (Dr Pepys).

Arch Intern Med. 1989;149(2):453-454. doi:10.1001/archinte.1989.00390020141031

• A 76-year-old woman presenting with generalized amyloidosis of the AA-type protein was found to have a left atrial myxoma. Retrospective estimation of the concentration of SAA protein, a serum precursor of AA amyloid, before and after surgical removal of the myxoma, showed that the SAA protein had disappeared after the operation. A common manifestation of myxoma is the development of a severe inflammatory syndrome that sometimes simulates rheumatic fever or bacterial endocarditis. However, to our knowledge, it has never been described in association with amyloidosis. We suggest that atrial myxoma should be added to the list of neoplastic and inflammatory diseases predisposing to AA amyloidosis.

(Arch Intern Med 1989;149:453-454)

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