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February 1989

Correlation Between Protein-to-Creatinine Ratio in a Single Urine Sample and Daily Protein Excretion

Arch Intern Med. 1989;149(2):467. doi:10.1001/archinte.1989.00390020151038

To the Editor.—Schwab et al1 have reported an excellent correlation between the protein-to-creatinine ratio in a single urine sample and the collection of protein in a 24-hour urine sample. This correlation remained accurate independent of the type of renal disease and of the degrees of protein-uria and renal function.

Using methodology identical to that of Schwab et al, we have compared the urinary protein-to-creatinine ratio with daily urinary protein excretion in 452 patients with significant proteinuria (>5 mg/kg/d). The patients were classified in five groups according to their renal function. Group A consisted of 107 patients with serum creatinine levels less than 133 μmol/L; group B, 135 patients with serum creatinine levels ranging from 133 to 266 μmol/L; group C, 103 patients with serum creatinine levels ranging from 267 to 532 μmol/L; group D, 88 patients with serum creatinine levels greater than 532 μmol/L; and group E, 19