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February 1989

Mental Testing With Metoprolol

Author Affiliations

Pueblo, Colo

Arch Intern Med. 1989;149(2):472-475. doi:10.1001/archinte.1989.00390020154044

To the Editor.—An article by Gengo and associates1 that showed greater improvement in mental testing with metoprolol is consistent with earlier data not referenced in their article, which included a report by Eisdorfer (Continued on page 474.) (Continued from page 472.) and coworkers2 that showed improvement in learning using propranolol in old men. Following the publication of this article, we undertook animal research studies showing that propranolol also enhanced learning in rats.3 The hypothesis of earlier studies was that this was due to decreased autonomic activity decreasing interference with central nervous system function. The current study,1 showing that there is more improvement with metoprolol, which is a more lipid-soluble β-blocker, lends credence to the converse hypothesis of direct central effect, and thus, is of considerable interest.

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