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April 1989

Disseminated Coccidioidomycosis With Peritonitis in a Patient With Acquired Immunodeficiency Syndrome: Prolonged Survival Associated With Positive Skin Test Reactivity to Coccidioidin

Author Affiliations


From the Infectious Disease Service (Dr Byrne) and the Pulmonary Disease Service (Dr Dietrich), Department of Medicine, Letterman Army Medical Center, Presidio of San Francisco.

Arch Intern Med. 1989;149(4):947-948. doi:10.1001/archinte.1989.00390040141032

• Coccidioidomycosis involving the lungs and the meninges occurred as the sole opportunistic infection in a patient with the acquired immunodeficiency syndrome (AIDS). Skin test reactivity to coccidioidin was present, but antibody response to coccidioidal antigens was markedly distinguished. Treatment with amphotericin B, administered intravenously for 3½ months and intrathecally for 13 months, resulted in a disease-free interval of one year. Subsequently, coccidioidal peritonitis developed, which responded to treatment with amphotericin B. However, 29 months after the initial diagnosis, the patient died of complications of hepatic encephalopathy resulting from alcoholic cirrhosis. To our knowledge, this patient represents the first reported case of coccidioidal peritonitis in AIDS and involves the most prolonged survival of a patient with coccidioidomycosis and AIDS. The presence of positive skin test reactivity to coccidioidin may have been a predictor of prolonged survival in this patient.

(Arch Intern Med 1989;149:947-948)