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April 1989

Intra-articular Amphotericin B Treatment of Sporothrix schenckii Arthritis

Author Affiliations

From the Departments of Medicine, University of Kansas College of Health Sciences and Hospital, Kansas City (Drs Downs, Hinthorn, and Liu), and Methodist Hospital, Topeka (Dr Mhatre), Kan.

Arch Intern Med. 1989;149(4):954-955. doi:10.1001/archinte.1989.00390040148035

• Arthritis caused by Sporothrix schenckii may not respond satisfactorily to a full course of intravenous amphotericin B therapy. Left untreated, the fungus continues to be recovered from cultures of joint fluid, and the patient typically has serious joint disability. We have shown In one patient with sporotrichosis of the knee that direct low-dose injections of amphotericin B can be performed safely, resulting in eradication of the fungus. The patient has had continued useful range of motion and weight bearing on the involved knee.

(Arch Intern Med 1989;149:954-955)

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