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May 1989

Clinical Manifestations of Human Parvovirus B19 in Adults

Author Affiliations

From the Department of Rheumatology, Bristol (England) Royal Infirmary (Drs Woolf, Campion, Chishick, Wise, and Dieppe); UK Transplant Service (Dr Klouda) and Public Health Laboratory (Dr Caul), Bristol; and Virus Reference Laboratory, Central Public Health Laboratory, Colindale (Dr Cohen), England. Dr Woolf is now with the Duke of Cornwall (England) Rheumatology Unit.

Arch Intern Med. 1989;149(5):1153-1156. doi:10.1001/archinte.1989.00390050111022

• Human parvovirus B19 has been associated with various clinical effects in a number of uncontrolled reports. To define the usual manifestations of B19 infection in adults and the factors that influence them we present a clinicoepidemiological study of an outbreak of B19 infection centered on a junior school. Four hundred fifty-three of 475 adults in this community were interviewed and blood was obtained for serological diagnosis. Fifty-four cases of recent infection were identified and were HLA typed. Fourteen of the cases were asymptomatic; 32 had an influenzalike illness; 23 a rash; and 26 an acute-onset polyarthropathy that was more common in women and lasted for up to 7 months. HLA-A, -B, and -C antigen frequencies were similar to a local control population and showed no association with symptoms except that HLA-DR1 was absent in those with persistent arthropathy.

(Arch Intern Med. 1989;149:1153-1156)