• The association of phenytoin and liver toxicity is well documented. This article describes a patient who underwent a trans sphenoidal resection of a pituitary tumor who developed phenytoin-induced hepatotoxicity that was masked by the simultaneous administration of corticosteroids for treatment of cerebral edema. In a patient receiving both medications, the systemic manifestations of the hypersensitivity to phenytoin may go unrecognized, leading to delayed identification of a potentially lethal complication of this commonly prescribed anticonvulsant.
(Arch Intern Med. 1989;149:1196-1197)
Lisker-Melman M, Hoofnagle JH. Phenytoin Hepatotoxicity Masked by Corticosteroids. Arch Intern Med. 1989;149(5):1196–1197. doi:10.1001/archinte.1989.00390050148032
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