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May 1989

Coexistence of Pyoderma Gangrenosum and Arteritis in Ulcerative Colitis

Author Affiliations

Fukuoka, Japan

Arch Intern Med. 1989;149(5):1226. doi:10.1001/archinte.1989.00390050170046

To the Editor.—We read with interest the article by Danzi1 in the February 1988 issue of the Archives in which extraintestinal manifestations of idiopathic inflammatory bowel disease was reviewed. Recently, we experienced a case of ulcerative colitis with unusual findings.

Report of a Case.—A 22-year-old man had diarrhea, malaise, and a fever, and was admitted to the hospital. Barium enema examination demonstrated involvement of the entire colon, with a complete lack of haustration and total colonic narrowing. A colonofiberscopic examination revealed that the mucosa was uneven, hyperemic, and bled easily. Microscopically, biopsy specimens from different levels of the rectum and colon showed chronic inflammation with proliferation of granulation tissues and infiltration of leukocytes; crypt abscesses were also observed. He was diagnosed as having ulcerative colitis (total colitis), and was treated conservatively with oral administration of prednisolone and sulfasalazine. Two months later he was markedly improved, and he

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