• Ten patients with acute meningitis caused by gram-negative bacteria were treated with pefloxacin intravenously for a mean period of 10 days. Eight patients responded clinically to pefloxacin treatment, and the causative organisms were eradicated from the cerebrospinal fluid in 9 of the 10 patients. Pefloxacin may offer a new, efficacious, and safe therapy for gram-negative meningitis.
(Arch Intern Med. 1989;149:1314-1316)
Segev S, Barzilai A, Rosen N, Joseph G, Rubinstein E. Pefloxacin Treatment of Meningitis Caused by Gram-negative Bacteria. Arch Intern Med. 1989;149(6):1314–1316. doi:10.1001/archinte.1989.00390060054011
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