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June 1989

Symptom Rating Scale for Assessing Hyperthyroidism

Author Affiliations

Los Angeles, Calif

Arch Intern Med. 1989;149(6):1466-1467. doi:10.1001/archinte.1989.00390060170047

To the Editor.—We read with interest the article by Klein et al1 concerning the construction of an index of symptoms to measure the severity of hyperthyroidism and response to treatment. The authors cite the diagnostic index devised by Crooks and coworkers2 stating that they did not apply this index of clinical signs and symptoms to treated patients. The Glasgow group did indeed modify their original diagnostic index by removing those signs (eg, palpable thyroid and exophthalmos) they thought unaffected by treatment to construct a therapy index,3 which they used to give a quantitative measure of the response to potassium perchlorate, methylthiouracil, and carbimazole.4

We have also previously constructed a clinical index of 10 signs and 10 symptoms to quantify the degree of hyperthyroidism and response to treatment.5 We compared serum thyroid hormone concentrations before therapy with the β-adrenergic blocker atenolol before thyroxine, and at the

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