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August 1989

Screening for Hepatocellular Carcinoma in High-Risk Individuals: A Clinical Review

Author Affiliations

From the Division of General Internal Medicine, Department of Medicine, University of California, San Francisco. Dr Regan is now in private practice, Redwood City, Calif.

Arch Intern Med. 1989;149(8):1741-1744. doi:10.1001/archinte.1989.00390080027007

• Hepatocellular carcinoma occurs primarily in individuals with chronic hepatitis B infection and cirrhosis. This tumor is curable only when diagnosed at an early stage and then surgically resected. Therefore, screening tests have been used to identify small tumors in high-risk patients. Currently, the most sensitive and specific tests available involve measurement of serum αfetoprotein levels and high-resolution ultrasonography. The results of these tests are often complementary in making a diagnosis. To be most cost-effective, the frequency of screening can be adjusted to the degree of risk of hepatocellular carcinoma.

(Arch Intern Med. 1989;149:1741-1744)

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