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August 1989

Therapeutic Radiation and Hyperparathyroidism: A Case-Control Study in Rochester, Minn

Author Affiliations

From the Department of Health Sciences Research (Ms Beard, and Drs O'Fallon and Melton), Endocrine Research Unit, Divsion of Endocrinology and Internal Medicine (Dr Heath), and Division of Radiation Oncology (Dr Earle and Mr Anderson), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Intern Med. 1989;149(8):1887-1890. doi:10.1001/archinte.1989.00390080135030

• A case-control study was conducted among residents of Rochester, Minn, to assess the influence of prior therapeutic radiation on the risk of primary hyperparathyroidism. Fifty-one cases of surgically proven primary hyperparathyroidism diagnosed from 1975 through 1983 were each matched by age and gender to two control subjects, with radiation exposure documented through preexisting medical records. The overall odds ratio for any prior therapeutic radiation therapy was 1.9 (95% confidence interval, 0.9 to 4.4) and it was 2.3 (95% confidence interval, 0.9 to 5.7) when limited to those with prior head and neck radiation. Among women, the figures were 2.9 (95% confidence interval, 1.1 to 7.5) for any prior therapeutic radiation and 3.4(95% confidence interval, 1.2 to 10.2) for head and neck exposure. This study confirms the association between primary hyperparathyroidism and prior therapeutic radiation exposure, at least for women in this population.

(Arch Intern Med. 1989;149:1887-1890)

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