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August 1989

An Ecogenetic Hypothesis for Lung Cancer in Women-Reply

Author Affiliations

New Haven, Conn

Wallingford, Conn

Arch Intern Med. 1989;149(8):1900. doi:10.1001/archinte.1989.00390080144034

In Reply.—We are pleased to respond to the comments of Drs Ness and Price, especially since they have restated concerns that we noted in our article, "An Ecogenetic Hypothesis for Lung Cancer in Women."1 We were also concerned that clinicians conducting interviews of hospitalized patients may be more likely to ask and record data about a family history of lung cancer for cases rather than for control subjects. To minimize bias from this problem, we chose only control subjects who had family history data in the record. While we would prefer structured interviews with patients (cases and control subjects), we believe our approach is preferable to collecting control data without recorded family history. We do not agree with Drs Ness and Price that assessing family risk "..... in terms of number of lung cancers among an explicitly defined number of relatives at risk" is a superior strategy. Restricting family history