• Autoantibodies reacting with the cytoplasm of granulocytes and monocytes (anticytoplasmic antibodies [ACPAs]) were found in 42 of 45 patients with active Wegener's granulomatosis (WG) (sensitivity, 93%). Specificity was tested in selected groups of patients with closely related diseases. Of 58 patients without a diagnosis of WG, 2 had ACPAs (specificity, 97%). The significance of ACPA titration for assessing or predicting disease activity was evaluated in a 16-month prospective study of 35 patients with WG. Seventeen relapses were observed and all were preceded by a significant rise of the ACPA titer. Anticytoplasmic antibodies are a specific and sensitive marker for active WG; a rising titer is a sensitive marker for the development of a relapse.
(Arch Intern Med. 1989;149:2461-2465)
Tervaert JWC, van der Woude FJ, Fauci AS, et al. Association Between Active Wegener's Granulomatosis and Anticytoplasmic Antibodies. Arch Intern Med. 1989;149(11):2461–2465. doi:10.1001/archinte.1989.00390110055012
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