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Article
December 1989

How Bad Are Diuretic-Induced Hypokalemia and Hypercholesterolemia?

Author Affiliations

Department of Internal Medicine University of Texas Southwestern Medical Center at Dallas 5323 Harry Hines Blvd Dallas, TX 75235-9030

Arch Intern Med. 1989;149(12):2649. doi:10.1001/archinte.1989.00390120021005
Abstract

For those who work in the hypertension field and for all practitioners who deal with hypertensive patients, Ed Freis is a hero, responsible for the first documentation that the treatment of moderate hypertension would save lives1 and for a steady stream of useful data over the past 20 years as the principal investigator of the Veterans Administration Cooperative Study Group. Moreover, Dr Freis was one of the first voices to be heard advising caution regarding the overtreatment of mild hypertension,2 despite his having been the one largely given credit for the current enthusiasm toward "early and aggressive therapy." Knowing how careful and thoughtful he is, I am sure he must have viewed the subsequent trend toward overly aggressive therapy as a problem he simply had to stand up to.

Therefore, I reviewed Dr Freis' article published in this issue of the Archives3as one who both admires

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