• From 1971 to 1972 (N=105) and 1986 to 1987 (N=160), parenteral drug abusers seropositive for hepatitis B virus (HBV) markers were screened for antibodies to the hepatitis delta virus (anti-HD). In both time frames anti-HD was independently associated with the hepatitis B surface antigen. It was observed that 31% of those positive for hepatitis B surface antigen from the early sample and 20% of those from the latter sample had detectable anti-HD, as opposed to 10% and 7%, respectively, of those negative for hepatitis B surface antigen. Anti-HD seropositivity was unrelated to gender and ethnicity, and in the 1971 and 1972 nationwide sample, its presence was unrelated to geographic location. The probability of manifesting anti-HD increased with the more HBV markers detected, particularly the number of different HBV antibody markers. We conclude that anti-HD was widespread in parenteral drug abusers at least as early as 1971, and that its expression was associated with hepatitis B surface antigen and the intensity of the immune response to HBV as evidenced by the number of different circulating HBV antibodies.
(Arch Intern Med. 1990;150:365-368)
Lange WR, Cone EJ, Snyder FR. The Association of Hepatitis Delta Virus and Hepatitis B Virus in Parenteral Drug Abusers: 1971 to 1972 and 1986 to 1987. Arch Intern Med. 1990;150(2):365–368. doi:10.1001/archinte.1990.00390140087019
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