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April 1990

Risk Factors for Thromboembolic Complications in Chronic Atrial Fibrillation: The Copenhagen AFASAK Study

Author Affiliations

From the Departments of Neurology (Drs Petersen, Helweg-Larsen, Boysen, and Godtfredsen) and Cardiology (Dr Kastrup), University Hospital, Rigshospitalet, Copenhagen, Denmark.

Arch Intern Med. 1990;150(4):819-821. doi:10.1001/archinte.1990.00390160077016

• As previously reported, 1007 patients with chronic atrial fibrillation participated in the Copenhagen AFASAK study. Before inclusion to trial, they all had a physical examination, chest roentgenogram, and echocardiogram with determination of left atrial size. This study evaluated the importance of cardiovascular risk factors for development of thromboembolic complications. To exclude any treatment effects on occurrence of thromboembolic complications, we included only the 336 patients from the placebo group. Using Cox's regression model, previous myocardial infarction was a significant risk factor for development of thromboembolic complications. Age, gender, heart failure, chest pain, hypertensive heart disease, diabetes, systolic and diastolic blood pressure, smoking, relative heart volume, and left atrial size were all without statistical importance.

(Arch Intern Med. 1990;150:819-821)