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September 1990

Antiphospholipid Antibodies Associated with Human Immunodeficiency Virus Infection-Reply

Author Affiliations

Los Angeles, Calif

Arch Intern Med. 1990;150(9):1975. doi:10.1001/archinte.1990.00390200149038

In Reply.—The data of Taillan et al are interesting and confirm the presence of anticardiolipin antibodies in patients with human immunodeficiency virus infection.1 We were struck by the frequency of anticardiolipin antibodies (29/74) in patients with asymptomatic human immunodeficiency virus infection, lending further support to the idea that the presence of elevated titers of anticardiolipin antibodies may be a reflection of the underlying viral infection. Although we are not entirely clear from the data provided how the actual frequency of the circulating lupus anticoagulant was obtained, they noted a high frequency (53.5%) using the tissue thromboplastin inhibition test. We prefer to use the kaolin clotting time method as described by Exner and coworkers2 because it is not influenced by warfarin therapy and can be interpreted in the face of a prolonged prothrombin time.

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