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October 1990

Liver Alterations in Acute Pneumonia

Author Affiliations

Barcelona, Spain

Arch Intern Med. 1990;150(10):2206. doi:10.1001/archinte.1990.00390210152036

To the Editor.—We have read with interest the work published by Sikuler et al1 in this issue of the Archives, and want to communicate our experience in liver biochemical abnormalities during acute infection. Prospectively, we studied 95 patients with pneumonia who went into Hospital General Vall d' Hebrón, Barcelona, Spain.2,3 In all patients we determined the following bilirubin and serum liver enzyme levels: aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and γ = glutamyl transpeptidase. Also, we determined two serum bile acid levels, choleglycine and sulfolithocholeglycine. Biochemical tests were performed by an autoanalyzer, except for the bile acids that were performed by radioimmu

noanalysis (Abbott Laboratories, North Chicago, Ill). At 7.1 ±4.4 days of pneumonia evolution, we found that 30% of patients presented high aspartate aminotransferase levels, 23% high alanine aminotransferase levels, 23% alkaline phosphatase, 45% γ = glutamyl transpeptidase, 34% choleglycine, and 64% sulfolithocholeglycine, respectively. In summary, 83% of

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