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April 1991

Angiofollicular Lymph Node Hyperplasia and Peripheral Neuropathy: Case Report and Literature Review

Author Affiliations

From the Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Md (Dr Scherokman), and the Hematology (Dr Vukelja) and Neurology (Dr May) Services, Walter Reed Army Medical Center, Washington, DC.

Arch Intern Med. 1991;151(4):789-790. doi:10.1001/archinte.1991.00400040127030

A man with multicentric angiofollicular lymph node hyperplasia and a polyclonal gammopathy developed a debilitating sensory-motor peripheral neuropathy that resolved with plasmapheresis and immunosuppressive therapy. Fourteen similar cases have been reported in the literature; however, to our knowledge, this is the first report of successful treatment with plasmapheresis. Severe peripheral neuropathy usually occurs in the setting of multicentric, plasma cell-type disease with hypergammaglobulinemia and is often responsive to immunosuppressive therapy.

(Arch Intern Med. 1991;151:789-790)

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