A man with multicentric angiofollicular lymph node hyperplasia and a polyclonal gammopathy developed a debilitating sensory-motor peripheral neuropathy that resolved with plasmapheresis and immunosuppressive therapy. Fourteen similar cases have been reported in the literature; however, to our knowledge, this is the first report of successful treatment with plasmapheresis. Severe peripheral neuropathy usually occurs in the setting of multicentric, plasma cell-type disease with hypergammaglobulinemia and is often responsive to immunosuppressive therapy.
(Arch Intern Med. 1991;151:789-790)
Scherokman B, Vukelja SJ, May E. Angiofollicular Lymph Node Hyperplasia and Peripheral Neuropathy: Case Report and Literature Review. Arch Intern Med. 1991;151(4):789–790. doi:10.1001/archinte.1991.00400040127030
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.