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April 1991

Afibrinogenemia and Hypobetalipoproteinemia in a Kindred

Author Affiliations

From the Lipoprotein and Atherosclerosis Research Program (Drs Lane and McConathy), Cardiovascular Biology Research Program (Dr Comp), Oklahoma Medical Research Foundation, and Oklahoma Blood Institute (Dr Gilcher), Oklahoma City.

Arch Intern Med. 1991;151(4):800-804. doi:10.1001/archinte.1991.00400040134032

A 3-year-old boy with minor bleeding problems had no plasma fibrinogen measured by both clottable assay and immunoprecipitation. Low normal fibrinogen levels were present in the mother and father. Markedly decreased plasma cholesterol and apolipoprotein B levels were found in the father, proband's brother, and the paternal side of the kindred. The proband and his mother had normal plasma total cholesterol and apolipoprotein B levels. These findings are compatible with autosomal dominant transmission of hypobetalipoproteinemia and autosomal recessive transmission of afibrinogenemia. Two members of the father's family had plasma cholesterol levels below the fifth percentile but elevated levels of fibrinogen (6.0 and 4.4 g/L). Both have symptomatic coronary heart disease. Finding coronary heart disease with very low cholesterol but elevated fibrinogen levels is consistent with fibrinogen levels being an independent risk factor for coronary heart disease.

(Arch Intern Med. 1991;151:800-804)