To the Editor.—
Eisen et al1 found no significant decrement in patient medication compliance between once- and twice-daily regimens. In a study of epilepsy patients,2 we also found a linear decline, but no statistically significant differences in compliance among one, two, or three daily doses (87%, 81%, 77%, respectively). The four-times-a-day regimen (39%) was significantly lower than all others (P<.05 for two and three doses, P<.01 for one dose daily). Unfortunately, Eisen et al mistakenly described our study outcome, because the table legend describing statistical differences was printed incorrectly in JAMA due to a copy editor's error. Although JAMA reported the error in a later issue, we wish to notify readers of the correct interpretation of our data. Indeed, we concur with Eisen et al that multiple daily dosing schedules are difficult for patients to maintain. Simplification of regimens and direct discussion about compliance are easy
Cramer JA. Medication Compliance in Epilepsy. Arch Intern Med. 1991;151(6):1236–1237. doi:10.1001/archinte.1991.00400060142033
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