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August 1991

Hemochromatosis, Iron, and Septicemia Caused by Vibrio vulnificus

Author Affiliations

From the Department of Surgery, University of Miami (Fla) School of Medicine (Drs Bullen and Ward and Mr Spalding); and the National Institute for Biological Standards and Control, London, England (Dr Gutteridge).

Arch Intern Med. 1991;151(8):1606-1609. doi:10.1001/archinte.1991.00400080096018

Vibrio vulnificus is killed by normal human blood but grows rapidly in blood from patients with hemochromatosis. It also grows in normal blood if the saturation of the transferrin is increased or if hematin, which contains iron, is added. It is suggested that the increased availability of iron in the blood of patients with chronic iron overload is responsible for their enhanced susceptibility to infection with V vulnificus.

(Arch Intern Med. 1991;151:1606-1609)