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September 1991

Cushing's Disease and Cutaneous Alternariosis

Author Affiliations

From the Departments of Endocrinology (Drs Guerin, Duquenne, Amiot, Ortega, and Hartemann) and Dermatology (Dr Barbaud) and Laboratory of Mycology (Dr Contet-Audonneau), Centre Hospitalo-Universitaire, Nancy, France.

Arch Intern Med. 1991;151(9):1865-1868. doi:10.1001/archinte.1991.00400090137024

Alternaria species are common plant pathogens, but a rare cause of human infection. We present a patient with cutaneous alternariosis that revealed a relapse of an old case of Cushing's disease. Immunosuppression following the excessive glucocorticoid production seemed to contribute to the development of dermatosis. We also present a review of the literature on the association of Cushing's disease and cutaneous alternariosis. Our case is unique because the ketoconazole therapy that we used was successful in the treatment of both diseases.

(Arch Intern Med. 1991;151:1865-1868)

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