Krakauer and Fachnie have pointed out the differences between men and women with regard to the associations between lipid measures and coronary artery disease observed in our study.1 Women in our study had higher average serum concentrations of total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B than did men, but these were offset by higher average concentrations of high-density lipoprotein cholesterol and apolipoprotein A-I, such that women had higher average apolipoprotein A-I/B ratios. Differences between the lipid measurements for patients with and without coronary artery disease were all in the same direction for women as for men. One important difference between men and women in our study was the prevalence of diabetes mellitus (25% in women vs 12% in men). The lower statistical power for these tests of association with coronary artery disease in women, and the effects of diabetes mellitus, and the use of sex hormones
Reinhart RA, Broste SK, Arndt MR. Gender and Lipids in Coronary Artery Disease-Reply. Arch Intern Med. 1991;151(9):1881–1882. doi:10.1001/archinte.1991.00400090147030
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