To the Editor. —
I read with interest the article by Greenberg and Bank1 on the prevalence of Helicobacter pylori in nonulcer dyspepsia. Their results are important as they emphasize that the frequency of H pylori increases with age in outpatients with nonulcer dyspepsia, but not in patients with peptic ulceration, implying that this infection may not be causally linked to nonulcer dyspepsia. However, they reported that H pylori was only present in 37% of patients with nonulcer dyspepsia and implied that this was not different from the expected prevalence rate in the general population. Unfortunately, it is unclear whether the somewhat low prevalence of H pylori in nonulcer dyspepsia relates to the diagnostic gold standard used, as only one antral biopsy specimen was obtained for urease testing; because infection can be patchy, this may have led to an underestimation of the prevalence of H pylori in all groups
Talley NJ. Prevalence of Helicobacter pylori in Nonulcer Dyspepsia. Arch Intern Med. 1991;151(11):2313–2314. doi:10.1001/archinte.1991.00400110141029
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