Christopher Columbus suffered from an arthritic disorder that began on his First Voyage to the New World. The disease was progressive, punctuated by painful flares in the lower extremities, and, at times, seemed to be associated with fever and ocular symptoms. During his Fourth Voyage and final years of life, Columbus was immobilized by his rheumatologic condition. This article uses contemporary historical accounts of Columbus' illness to trace the clinical features of his disease.
(Arch Intern Med. 1992;152:274-277)
Hoenig LJ. The Arthritis of Christopher Columbus. Arch Intern Med. 1992;152(2):274–277. doi:10.1001/archinte.1992.00400140028008
Browse and subscribe to JAMA Network podcasts!
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: