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February 1992

Availability of Zirconium in Topical Antiperspirants-Reply

Author Affiliations

Camden, NJ

Worcester, Mass

Arch Intern Med. 1992;152(2):422-426. doi:10.1001/archinte.1992.00400140153040

In Reply.—  We graciously accept Lisi's correction. We were in error in omitting the word "aerosolized" in our sentence discussing the zirconium-containing products that were banned by the Food and Drug Administration.1 The Federal Register of July 5, 1975, reported the following: "Certain zirconium compounds have caused human skin granulomas and toxic effects in the lungs and other organs of experimental animals.... When used in an aerosol form, some zirconium will reach the deep portions of the lungs of users of these products.... Unlike the skin, the lung will not reveal the presence of granulomatous changes until they have become advanced and, in some cases, permanent.... Earlier in this report, the Panel has given its analysis of the risk-benefit considerations involved in non—aerosolized zirconium-containing antiperspirants. The conclusion was that these nonaerosolized antiperspirants are reasonably safe."2The capacity of zirconium compounds to cause granulomas