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May 1992

Angiotensin-Converting Enzyme Inhibitors and Glycosuria

Author Affiliations

From the Department of Internal Medicine, University of Arizona, Tucson.

Arch Intern Med. 1992;152(5):1081-1083. doi:10.1001/archinte.1992.00400170151027

Renal glycosuria associated with the use of angiotensinconverting enzyme inhibitors has been previously reported in two patients. A third patient was studied who developed isolated glycosuria associated with lisinopril therapy. As in the two previously described patients, this patient had a normal serum glucose level, underlying hypertension, and onset of glycosuria between 2 and 16 weeks after initiation of therapy with an angiotensin-converting enzyme inhibitor. The patient had renal artery stenosis with elevated renin levels. Age, time until resolution of glycosuria, and a rise in serum creatinine level did not have a consistent relationship with glycosuria associated with angiotensin-converting enzyme inhibitor therapy. Since glycosuria was the only defect noted, without evidence of any other urinary solutes, angiotensin-converting enzyme inhibitors may exert an effect on the glucose-specific proximal tubule transport system.

(Arch Intern Med. 1992;152:1081-1083)