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June 1992

Effects of Nonsteroidal Anti-inflammatory Drugs on Endogenous Gastrointestinal Prostaglandins and Therapeutic Strategies for Prevention and Treatment of Nonsteroidal Anti-inflammatory Drug—Induced Damage

Author Affiliations

From the Medical Service, Department of Veterans Affairs Medical Center, and Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas.

Arch Intern Med. 1992;152(6):1145-1155. doi:10.1001/archinte.1992.00400180017003

Although nonsteroidal anti-inflammatory drugs (NSAIDs) are effective for pain relief and treatment of arthritis, they can induce gastric and duodenal ulcers and life-threatening complications. The mechanisms of their anti-inflammatory action and their gastroduodenal toxic effects are related, in part, to inhibition of prostaglandin synthesis. This review article discusses prostaglandins, their functions in the gastrointestinal tract, anti-inflammatory actions of NSAIDs, and mechanisms by which NSAIDs produce gastroduodenal ulcers. Also reviewed are risk factors associated with the development of NSAID-related ulcers and pharmacologic strategies for the prevention and treatment of NSAID-induced ulcers.

(Arch Intern Med. 1992;152:1145-1155)

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