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June 1992

False Positive

Author Affiliations

Mt Kisco, NY

Arch Intern Med. 1992;152(6):1331. doi:10.1001/archinte.1992.00400180167035

To the Editor. —  Corpuz et al1 erroneously concluded that up to 27% of patients presenting to a Lyme center had a false-positive test result. These patients had positive serologic findings yet failed the Centers for Disease Control (Atlanta, Ga) criteria.The Centers for Disease Control provides a very restrictive definition for epidemiologic purposes, not for clinical management. The Centers for Disease Control definition for Lyme disease does not include symptoms such as arthralgias, myalgias, fibromyalgia, paresthesias, headache, fatigue, and palpitations.2Rahn et al,3 in a recent article, emphasize the need to exercise clinical judgment rather than a rigid adherence to a case definition. Treatment of patients with possible Lyme disease not meeting the Centers for Disease Control criteria might reduce the incidence of late neurologic sequelae of Lyme disease for adults4 and children.5A misdiagnosis of false-positive Lyme disease might lead a physician to withhold

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