In Reply. —
We agree that the Centers for Disease Control (Atlanta, Ga) definition of Lyme disease is useful for epidemiologic purposes. To conduct a study of this kind, the most rigorous definition of Lyme disease should be used. Nowhere in our article1 was there stated that this definition was used for clinical management. What was stated was that our results emphasize the need for improved and standardized Lyme assays and underline their use only as adjuncts in the diagnosis of Lyme disease. We agree with Cameron that clinical judgment should always be used when evaluating either seropositive or seronegative patients with symptoms of the disease. The 11 patients whom we described as symptomatic but not meeting the Centers for Disease Control case criteria have been followed up and none of them has developed evidence of either late neurologic or arthritic sequelae of Lyme disease.
Singer C, Corpuz M, Hilton E. False Positive-Reply. Arch Intern Med. 1992;152(6):1331. doi:10.1001/archinte.1992.00400180167036
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