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July 1992

Herpes Simplex Virus Associated With Recurrent Stevens-Johnson Syndrome: A Management Strategy

Author Affiliations

From the Divisions of Allergy-Immunology (Drs Detjen and Patterson) and Infectious Diseases (Drs Noskin and Phair), Department of Medicine, Northwestern University Medical School, Chicago, Ill. Dr Loyd is in private practice, Libertyville, III.

Arch Intern Med. 1992;152(7):1513-1516. doi:10.1001/archinte.1992.00400190131024

We describe a 36-year-old man with recurrent Stevens-Johnson syndrome, which became progressively more severe over a 13-year period. His episodes were apparently preceded by herpes simplex virus oral mucosal infections. A management protocol, including immediate therapy with acyclovir and prednisone at the onset of herpes simplex virus oropharyngitis, is outlined. This management strategy has successfully prevented four subsequent episodes of progression to Stevens-Johnson syndrome. Thus, Stevens-Johnson syndrome associated with herpes simplex virus may be prevented by early use of acyclovir and prednisone.

(Arch Intern Med. 1992;152:1513-1516)