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February 8, 1993

Erythropoietin: Biology and Clinical Applications

Author Affiliations

From the Bone Marrow Transplantation Program, George Washington University School of Medicine, Washington, DC.

Arch Intern Med. 1993;153(3):298-304. doi:10.1001/archinte.1993.00410030014003

Hemopoiesis is a complex process that underlies the production of highly specialized cells. The mechanisms involved in this process include positive and negative feedback by humoral activities, pluripotent stem cell self-renewal and differentiation, and local interactions between stromal components of the hemopoietic microenvironment and various stem and progenitor cells.1