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May 10, 1993

Reversible Parkinsonism Induced by Hypercalcemia and Primary Hyperparathyroidism

Author Affiliations

From the Department of Medicine, Queen's University at Kingston (Ontario).

Arch Intern Med. 1993;153(9):1134-1136. doi:10.1001/archinte.1993.00410090076010

We describe a patient who had the recent onset of both primary hyperparathyroidism and parkinsonism. Surgical removal of a parathyroid adenoma was followed by spontaneous resolution of the parkinsonism. Hypoparathyroidism and other disorders of calcium metabolism are recognized causes of secondary parkinsonism, while hyperparathyroidism is not. We review the relevant literature, which supports the hypothesis that hypercalcemia may have induced cytotoxic changes in the basal ganglia of this patient.

(Arch Intern Med. 1993;153:1134-1136)