The inverse association of serum cholesterol levels and noncardiovascular causes of death1 may have been due to an increased risk in subjects lowering their cholesterol concentration by diet or drugs.2 This hypothesis is supported by diurnal variation of serotonin and suicide3-5 and by decreased serotonergic-mediated inhibition of dopamine6,7 subserving alcohol-seeking behavior8 and mood.9,10 The fact that delay-dependent speeding of reaction time, reflecting motor readiness, is abolished by depletion of dopamine suggests monitoring behavioral correlates of mood, ie, speech hesitation and switching pauses,11,12 to clarify the etiologic relationships of these inverse associations.1
Friedman EH. Low Serum Cholesterol Levels and Morning Suicide. Arch Intern Med. 1993;153(10):1268–1271. doi:10.1001/archinte.1993.00410100090016
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