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December 27, 1993

The Loyola University Lung Transplant Experience

Author Affiliations

From the Loyola University Lung Transplantation Group; and Departments of Medicine (Drs Doud and Garrity) and Thoracic and Cardiovascular Surgery (Ms McCabe and Dr Montoya), Loyola University of Chicago, Stritch School of Medicine, Maywood, Ill.

Arch Intern Med. 1993;153(24):2769-2773. doi:10.1001/archinte.1993.00410240077009

Background:  We reviewed our experience with isolated lung transplantation at Loyola University Medical Center, Maywood, Ill. From April 1990 through June 1992, 33 lung transplantations for end-stage pulmonary disease were performed (30 single lung, three bilateral single lung). Recipient diagnoses include chronic obstructive pulmonary disease, α1-antiprotease deficiency, pulmonary fibrosis, primary pulmonary hypertension, Eisenmenger's syndrome, sarcoidosis, cystic fibrosis, bronchiectasis, and bronchiolitis obliterans.

Methods:  For patients who underwent transplantation for end-stage obstructive airway disease, we retrospectively reviewed functional indexes before and after transplantation. In addition, the overall survival rate was determined.

Results:  Successful transplantation resulted in a marked improvement in functional capacity. Singlelung transplantation for end-stage obstructive airway disease resulted in a threefold improvement in the 1-second forced expiratory volume, from 0.49 to 1.64 L. The actual survival for all isolated lung transplant recipients (including both single-lung and bilateral single-lung procedures) was 73%, with a 15% 30-day mortality.

Conclusion:  Isolated lung transplantation can significantly improve functional capacity as well as the quality of life in patients with end-stage lung disease.(Arch Intern Med. 1993;153:2769-2773)