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December 27, 1993

Giant Splenomegaly and Refractory Hypercalcemia due to Extrapulmonary Sarcoidosis: Successful Treatment by Splenectomy

Author Affiliations

From the Department of Internal Medicine, Divisions of Pulmonary and Critical Care Medicine (Dr Gyetko) and Gastroenterology (Dr Scheiman), Ann Arbor (Mich) Veterans Affairs Medical Center; and the Department of Internal Medicine, University of Michigan Medical School, Ann Arbor (Dr Kruithoff).

Arch Intern Med. 1993;153(24):2793-2796. doi:10.1001/archinte.1993.00410240105013

Sarcoidosis is a granulomatous disease of unknown origin with a variable clinical presentation. The presenting complaint is usually referable to the lung. We describe an unusual presentation of sarcoidosis in a young black man who received medical attention for evaluation of pancytopenia, giant splenomegaly, and marked, refractory hypercalcemia. After extensive evaluation, including exploratory laparotomy, he was found to have sarcoidosis, with extensive involvement of his spleen, liver, and abdominal lymph nodes. Pulmonary involvement was notably absent, with no suggestive findings radiographically on gallium citrate Ga 67 scanning or on bronchoscopy with transbronchial biopsy. This patient underwent splenectomy and, following removal of the massive splenic granuloma burden, the hypercalcemia resolved completely with no other therapy.

(Arch Intern Med. 1993;153:2793-2796)